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  • 标题:Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all species: cupric chelate of amino acids hydrate, based on a dossier submitted by Zinpro Animal Nutrition Inc.
  • 本地全文:下载
  • 作者:Gabriele Aquilina ; Alex Bach ; Vasileios Bampidis
  • 期刊名称:EFSA Journal
  • 印刷版ISSN:1831-4732
  • 出版年度:2013
  • 卷号:11
  • 期号:2
  • DOI:10.2903/j.efsa.2013.3107
  • 出版社:European Food Safety Authority (EFSA), Parma
  • 摘要:Cupric chelate of amino acids hydrate is safe for all animal species/categories up to the authorised maximum of total copper content in complete feed. Consumption surveys include copper from foodstuffs of animal origin. Since the supplementation of animal feed with copper-containing compounds has not essentially changed over the last decade, no change in the contribution of foodstuffs originating from supplemented animals to the overall copper intake of consumers is expected. No concerns for consumer safety are expected from the use of cupric chelate of amino acids hydrate in animal nutrition, which would substitute for other copper sources. The additive should be considered as a skin and eye irritant and, owing to its amino acid/peptide component, as a skin/respiratory sensitiser. Potential risks to soil organisms have been identified as a result of the application of piglet manure. Levels of copper in other types of manure are too low to create a potential risk within the timescale considered. There might also be a potential environmental concern related to the contamination of sediment resulting from drainage and the run-off of copper to surface water. In order to draw a final conclusion, further model validation is needed and some further refinement to the assessment of copper-based feed additives in livestock needs to be considered, for which additional data would be required. The use of copper-containing additives in aquaculture up to the authorised maximum of total copper content in complete feeds is not expected to pose an appreciable risk to the environment. The extent to which copper-resistant bacteria contribute to the overall antibiotic resistance situation cannot be quantified at present. Cupric chelate of amino acids hydrate is recognised as an efficacious source of copper to meet animal requirements.
  • 关键词:Nutritional additive; compounds of trace elements; cupric chelate of amino acids hydrate; safety; environment; efficacy
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