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  • 标题:rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles
  • 本地全文:下载
  • 作者:G Fischer von Mollard ; G A Mignery ; M Baumert
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1990
  • 卷号:87
  • 期号:5
  • 页码:1988-1992
  • DOI:10.1073/pnas.87.5.1988
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:rab3, a low molecular weight GTP-binding protein, is primarily expressed in brain, where it is present in soluble and membrane-bound forms. Membrane-bound rab3 in brain is exclusively localized on synaptic vesicles, the secretory organelles of the synapse that store and release neurotransmitters. rab3 is also expressed in endocrine tissues such as the adrenal medulla, where it is found together with other synaptic vesicle proteins on microvesicles distinct from chromaffin granules. The tight binding of rab3 to membranes correlates with hydrophobic modifications that are different in the membrane-bound and soluble forms of rab3. The results demonstrate the exclusive targeting of a small GTP-binding protein to secretory vesicles of a subset of the regulated pathway of secretion.
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