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  • 标题:Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors
  • 本地全文:下载
  • 作者:Chiara Chiabrando ; Fausto Avanzini ; Claudia Rivalta
  • 期刊名称:Trials
  • 印刷版ISSN:1745-6215
  • 电子版ISSN:1745-6215
  • 出版年度:2002
  • 卷号:3
  • 期号:1
  • 页码:5
  • DOI:10.1186/1468-6708-3-5
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:

    Background

    Antioxidant supplementation with vitamin E had no effect in the prevention of cardiovascular diseases (CVD) in three recent large, randomized clinical trials. In order to reassess critically the role of vitamin E in CVD prevention, it is important to establish whether these results are related to a lack of antioxidant action.

    Methods

    We examined the in vivo antioxidant effect of vitamin E (300 mg/day for about three years) in 144 participants in the Primary Prevention Project (females and males, aged ≥ 50 y, with at least one major CV risk factor, but no history of CVD). Urinary 8-epi-PGF (isoprostane F-III or 15-F2t-isoP), a validated biomarker of lipid peroxidation, was measured by mass spectrometry.

    Results

    Urinary excretion of 8-epi-PGF [pg/mg creatinine, median (range)] was 141 (67–498) in treated and 148 (76–561) in untreated subjects (p = 0.10). Taking into account possible confounding variables, multiple regression analysis confirmed that vitamin E had no significant effect on this biomarker. Levels of 8-epi-PGF were in the normal range for most subjects, except smokers and those with uncontrolled blood pressure or hyperglycemia.

    Conclusions

    Prolonged vitamin E supplementation did not reduce lipid peroxidation in subjects with major cardiovascular risk factors. The observation that the rate of lipid peroxidation was near normal in a large proportion of subjects may help explain why vitamin E was not effective as an antioxidant in the PPP study and was ineffective for CVD prevention in large scale trials.

  • 关键词:Vitamin E; cardiovascular prevention; lipid peroxidation; F2-isoprostane; hypertension
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