首页    期刊浏览 2022年06月29日 星期三
登录注册

文章基本信息

  • 标题:In Vitro Effects of Paclitaxel and Cremophor EL on Human Riboflavin Transporter SLC52A2
  • 本地全文:下载
  • 作者:Hitomi Hino ; Mingdong Yang ; Pooja Dalvi
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2020
  • 卷号:43
  • 期号:1
  • 页码:175-178
  • DOI:10.1248/bpb.b19-00377
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Paclitaxel, a mitotic inhibitor with anti-cancer effects, is dissolved in Cremophor EL (CrEL). However, peripheral neuropathy is a known side effect. As one of the mechanisms of the neuropathy, mitochondrial dysfunction has been proposed, while peroxidation products are involved in the cause of CrEL-induced neurotoxicity. Riboflavin is an essential nutrient required for ATP production in mitochondria and has an antioxidant role as a coenzyme for glutathione. Therefore, riboflavin transporters might play a key role to mitigate neuropathy. However, it is unclear whether paclitaxel and CrEL affect these transporters. In this study, human riboflavin transporter SLC52A2 was used to analyze the effects of paclitaxel and CrEL. CrEL, but not paclitaxel, inhibited uptake of riboflavin in human embryonic kidney 293 cells transfected with the SLC52A2 expression vector, suggesting that altered riboflavin disposition may be involved in the pathogenesis of paclitaxel/CrEL toxicity.
  • 关键词:Cremophor EL;riboflavin;SLC52A2;paclitaxel;peripheral neuropathy
国家哲学社会科学文献中心版权所有