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  • 标题:A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA
  • 本地全文:下载
  • 作者:Yueh-Lung Wu ; Carol P. Wu ; Catherine Y. Y. Liu
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2011
  • 卷号:1
  • 期号:1
  • DOI:10.1038/srep00060
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:

    Heliothis zea nudivirus-1 (HzNV-1) is an insect virus previously known as Hz-1 baculovirus. One of its major early genes, hhi1, is responsible for the establishment of productive viral infection; another gene, pag1, which expresses a non-coding RNA, is the only viral transcript detectable during viral latency. Here we showed that this non-coding RNA was further processed into at least two distinct miRNAs, which targeted and degraded hhi1 transcript. This is a result strikingly similar to a recent report that herpes simplex virus produces tightly-regulated latent specific miRNAs to silence its own key early transcripts. Nevertheless, proof for the establishment of viral latency by miRNA is still lacking. We further showed that HzNV-1 latency could be directly induced by pag1-derived miRNAs in cells infected with a pag1-deleted, latency-deficient virus. This result suggests the existence of a novel mechanism, where miRNAs can be functional for the establishment of viral latency.

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    © 2011 Macmillan Publishers Limited. All rights reserved

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