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  • 标题:Effect of temporal fluctuation of selection coefficient on gene frequency in a population
  • 本地全文:下载
  • 作者:N Takahata ; K Ishii ; H Matsuda
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1975
  • 卷号:72
  • 期号:11
  • 页码:4541-4545
  • DOI:10.1073/pnas.72.11.4541
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The diffusion equations describing the change of gene frequencies are extended to indlude the effect of temporal fluctuation of selection coefficient that may persist for some generations. The equilibrium distribution of gene frequencies and the fixation probability of a mutant gene are obtained from the extended equations. Comparison is made with the experimental data on protein polymorphism. A possible bearing of the fluctuation of selection coefficient on the problem of molecular evolution is discussed in relation to the neutral theory.
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