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  • 标题:Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales)
  • 本地全文:下载
  • 作者:Chunmei Chen ; Qingyi Tong ; Hucheng Zhu
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2016
  • 卷号:6
  • DOI:10.1038/srep18711
  • 出版社:Springer Nature
  • 摘要:Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug ( Armadillidium vulgare ), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z ( 1 and 3 – 9 ) and 7- O -acetylarmochaetoglobin S ( 2 ), together with eight structurally related known analogues ( 10 – 17 ). Their structures and absolute configurations were elucidated by spectroscopic analyses. Among them, compound 2 presents to be the first member of chaetoglobosin family with an acetyl group, and compounds 3 represents the first chaetoglobosin characterized by an 2′,3′-epoxy-indole moiety. The discovery of these new compounds revealed the largely untapped chemical diversity of cytochalasans and enriched their chemical research. Compounds 1 – 9 were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds 8 and 9 exhibited significant cytotoxic activities with IC50 values ranging from 10.45 to 30.42 μ M.
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