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  • 标题:Diagnostic ability of %p2PSA and prostate health index for aggressive prostate cancer: a meta-analysis
  • 本地全文:下载
  • 作者:Wenying Wang ; Meilin Wang ; Li Wang
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2014
  • 卷号:4
  • DOI:10.1038/srep05012
  • 出版社:Springer Nature
  • 摘要:The role of [-2]proPSA (p2PSA) based diagnostic tests for the detection of aggressive prostate cancer (PCa) has not been fully evaluated. We conducted a meta-analysis to evaluate the diagnostic performance of p2PSA/free PSA (%p2PSA) and prostate health index (Phi) tests for PCa and to evaluate their ability in discriminating between aggressive and non-aggressive PCa. A total of 16 articles were included in this meta-analysis. For the detection of PCa, the pooled sensitivity, specificity, and AUC were 0.86 (95% CI, 0.84–0.87), 0.40 (95% CI, 0.39–042) and 0.72 (95% CI, 0.67–0.77) for %p2PSA respectively, and were 0.85 (95% CI, 0.83–0.86), 0.45 (95% CI, 0.44–0.47) and 0.70 (95% CI = 0.65–0.74) for Phi, respectively. In addition, the sensitivity for discriminating PCa between higher Gleason score (≥7) and lower Gleason score (
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