首页    期刊浏览 2023年02月08日 星期三
登录注册

文章基本信息

  • 标题:Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats
  • 本地全文:下载
  • 作者:Yasuhiko Ohkaru ; Natsuko Arai ; Hitoshi Ohno
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:2010
  • 卷号:56
  • 期号:2
  • 页码:215-220
  • DOI:10.1248/jhs.56.215
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The purpose of this study was to elucidate the effects of dexamethasone, a synthetic glucocorticoid, on the immune system by analyzing the number of white blood cells (WBCs) over the course of hours and days of dexamethasone administration. Dexamethasone was given as either a single dosage [1.0 mg/kg body weight (BW); subcutaneous injection (s.c.)] or as a daily dosage (1.0 mg/kg BW per day; s.c.) for 10 days for the hourly and daily assessment of changes in the number of white blood cells, respectively. A single administration of dexamethasone markedly decreased the number of total WBCs, as well as the number of lymphocyte, monocyte, neutrophil and eosinophil subsets with a nadir at 8 hr post-injection. The number of these cells recovered to the control levels at 24 hr. The numbers of total WBCs, lymphocytes, monocyte, eosinophil and basophil were reduced by the daily administration of dexamethasone. However, the number of neutrophil was significantly higher at days 2 and 8 after the injection. These results suggest that glucocorticoid-mediated immunosuppressions are at least partly attributable to quantitative changes in the number of circulating WBCs.
  • 关键词:dexamethasone;white blood cell;lymphocyte;glucocorticoid
国家哲学社会科学文献中心版权所有